TYPES OF GENOTYPES!

Dear beautiful viewers, I have come to realize that, there are more things to know about "Genotype". I'm glad to share them with you here. I will be pointing a light of great awareness to you as we look into GENOTYPE PT 2. Please stay connected as the light gets to you.

One of my colleague shared a story with me about an advanced man who should be in his late 30's or thereabout that was rushed to the hospital A/E. It happened that the man was having crises (I mean sickle crises) and his was so bad, but thank God he was revived by the doctor and nurses. So when he regained himself, the doctor approached him and began discussing with him, he then asked him if such a thing has ever happened to him and if he knew what it meant? But guess the man's answer. The man said he hasn't experienced such before and that brought the first shock. Already, the doctor from his test and diagnosis knew what the man was facing and the reason. The man was a carrier of sickle cell disease but he never had idea and he has never had any crises aside from the one he had that day. Everyone felt compassionate for the man, that was rare case. That could be the beginning of the man's Sickle crises the doctor said to the nurses privately. Hmm, so sad but true. Thank God medical attention was given to man so fast, the man would have wallowed in pain and in shortness of breath at the same time. The doctor had to cheer him up and gave him some professional advice and that stared up hope inside of the man and he felt better at the end.

I was stunned when I heard that was his first crises as a SS.

I'd love and advice that you get your Genotype checked and stick to a partner that you both are compatible together, so you don't fall into any unimaginable and life threatening scenery or regrets. These guess games are unnecessary when you can simply get tested to know what you and your spouse's blood group and genotype are. Personally I've met with some beautiful people that are victim of this from their parents. 

I remember a patient I met during my clinical internship, she had sickle cell disease and when her crises started, I cried so much, I have never witnessed such in my life, my God, you need to see her scream even more than the Pregnant women undergoing labour (sad), Huhh, she kept clinching her feet and hitting her bed groaning in pains and sadly, the NSAID given to her to relieve pain wasn't working as expected. She later opened up that she had used and even abused all of the med that the doctors prescribed for her before i.e whenever she had her crises. Noting worked for her up until an alternative therapy was given to her. I really felt her pains. No one deserves to go through those pains I life.

THERE ARE SIX TYPES OF GENOTYPES

I was told while growing up that there are three types of Genotype: 

- AA

- AS

- SS. But thank God for research, however there are more three added to that, such as:

- AC

- SC

- CC.

On my previous blog post, I said the Blood Genotype: Is the type of haemoglobin in your red blood cells. 

Haemoglobin in the red blood cells(RBCs) carries oxygen to all parts of the body. And it is from the common haemoglobin A that the various Genotype derived their character when it changes.

Without haemoglobin the blood won't get to other part of the systems and thereafter, there will be shortage of oxygen and blood.

1) GENOTYPE AA : 

This is present when a person inherits a Hemoglobin A gene from each parent (AA), that person will have normal hemoglobin and normal blood shape

AA = Normal Hemoglobin.

2) GENOTYPE AS: 

This is due to the inherited haemoglobin A trait and a S trait from each parents respectively. 

(The S is sickle cell trait, this actually means the blood is not in a normal shape but sickle shaped)

I want you to know that AS is not a mild form of sickle cell anemia. An AS individual doesn't have any symptom or issues there are just carrier of the S trait but not having the disease. However, there is reason for concern. When both parents have sickle cell trait (AS), their children may inherit two genes for sickle hemoglobin and the children may have Sickle Cell Anemia which will cause them serious life threatening crises.

 3) GENOTYPE SS :

This is also known as Sickle Cell Anemia. If a person inherits a gene for Hemoglobin S from both parents (SS), that person will definitely have sickle cell anemia. In sickle cell anemia the hemoglobin releases too much oxygen, causing the normallyround blood cells to be sickle shaped. These sickle cells tend to die more quickly than normal red blood cells and then the body does not receive enough oxygen. This may cause the person to be pale, short of breath and easily tired.

NOTE: BOTH PARENTS MUST HAVE AT LEAST ONE GENE FOR HEMOGLOBINS TO HAVE A CHILD WITH SICKLE CELL ANEMIA.

4) GENOTYPE AC : 

This genotype results from haemoglobin C and A. The individual with AC inhirited the normal Haemoglobin from one parent and the other C gene from the other parent. Approximately one in every 50 black Americans has Hemoglobin C trait. It's though rare in this part of the nation. If you have someone with this if love to meet with the person, I want you to know that AC is not a disease and there are no health problems associated with it.

AC = Hemoglobin C Trait

5) GENOTYPE SC: 

The person inherits a gene for Hemoglobin S from one parent and a gene for Hemoglobin C from the other parent, that person will have sickle cell andHemoglobin C disease (SC disease). This disease may produce symptoms similar to sickle cell anemia oorHemoglobin C disease. In some cases, it may be mild and then have few symptoms while others may be more severe and have many symptoms. Symptoms of this disease usually appear during the first 10 years of life.

Sometimes they first appear when a woman becomes pregnant.

These women may experience a higher rate of complications

during pregnancy. SC disease is considered to be less severe than

sickle cell anemia; however, damage to hip joints and the retina are

more common in persons with SC disease. Approximately one out

of every 1,000 black Americans has SC disease.

SC = Sickle Cell Hemoglobin C Disease

Note: SC disease is less Severe than Sickle Cell Anemia.

6) GENOTYPE CC: 

One with CC genotype, has Hemoglobin C Disease. When the person inherits a gene for Hemoglobin C from both parents (CC), that person will have Hemoglobin C disease. This disease may produce mild to moderate anemia, jaundice, enlarged spleen and gallstones. However, some people with Hemoglobin C disease do not have any of these symptoms.

Hemoglobin C disease is relatively rare and appears in approximately one out of every 10,000 black Americans.

CC = Hemoglobin C Disease

SS, SC & CC are the genotype that goes with lot of health crises especially Anemia.

Next week I'll be wrapping up this series with GENOTYPE COMPATIBILITY and the IMPORTANCE OF KNOWING YOUR HAEMOGLOBIN TYPE.

Your favourite Nurse Favour, loves you all  Thank you for joining in. 

PS: If this post was Helpful, please and please do justice by sharing this to others.

I'd love to hear from you, send all your questions to the comment section and you'll get reply as soon as I check it out. 

Don't forget to stay healthy, check your Genotype status and whatever the results shows kindly tell me and remember there is "Hope".

 #healthspecialist #goodhealththerapist #healthblogger